The brainstem is a complex and early-developing brain region that is responsible for sensory, motor, autonomic, and critical-for-life functions. However, technological barriers have prevented researchers from being able to examine substructures of the brainstem with neuroimaging. In this research, we will examine specific white matter tracts and nuclei within the brainstem in relation to the sensorimotor and core symptom challenges commonly experienced by children on the autism spectrum. Successful completion of this research will help us understand the brain basis of the sensory, motor, and core symptoms in autism.